Creates a permanent, statutory Advisory Committee on Immunization Practices (ACIP) with defined duties, membership rules, meeting and recordkeeping requirements, and authorizes funding through fiscal year 2029. It requires ACIP advice to be based on the best available, peer‑reviewed scientific evidence and sets procedures for how the CDC Director and HHS Secretary must handle, publish, or explain adoption or non‑adoption of ACIP recommendations.

Also raises the evidentiary bar for changing the Vaccine Injury Table: removal or other modification of a vaccine or listed injuries must be supported by a preponderance of the best available scientific evidence regarding the vaccine’s safety or efficacy, while preserving the Secretary’s authority to add new vaccines to the Table.