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Directs NIH to strengthen its support, guidance, review, and incentives for humane, human‑relevant nonanimal research methods; creates a new National Center to coordinate alternatives to animal research and testing; and requires entities that receive federal research/testing funds (and federal agencies that use animals) to report animal use counts and submit public plans to reduce those numbers. The bill sets timelines for reporting (initial reports within two years, then biennially) and defines covered animals to include live nonhuman vertebrates and cephalopods.
The bill aims to accelerate development and adoption of human-relevant, nonanimal research methods—improving scientific relevance and transparency—while imposing new costs, administrative burdens, and a risk of diverting NIH resources or delaying some research if alternatives are not yet ready.
Patients — research may become more predictive of human biology, potentially reducing drug failures and improving safety and efficacy of treatments.
Researchers and scientists — will receive targeted funding, training, and resources to develop and validate human-relevant, nonanimal research methods, increasing research capacity in these approaches.
Researchers, institutions, and federal agencies — a statutory National Center would coordinate federal efforts on alternatives, reduce duplication, and improve cross-agency efficiency and oversight.
Taxpayers and other NIH-funded research — creating a new center and shifting resources could divert NIH funding from existing priorities and raise federal administrative costs.
Researchers, institutions, and nonprofits — new documentation, searches, biennial reduction plans, and reporting requirements will increase administrative and compliance burdens and associated costs.
Patients and research progress — stricter pre‑animal evaluation requirements or premature emphasis on alternatives could delay some animal-based studies and slow medical advances where alternatives are not yet validated.
Introduced February 13, 2025 by Ken Calvert · Last progress February 13, 2025