Sponsors (17)
The bill shifts federal support, oversight, and reporting toward developing and adopting validated non‑animal, human‑relevant research methods—potentially improving patient‑relevant science and reducing animal use—while creating new federal costs, added administrative burdens, and some risk of short‑term research delays and institutional strain.
Researchers will get a dedicated NIH center, funding, coordination, and training to develop, validate, and adopt non‑animal, human‑relevant research methods.
Patients (including those with chronic conditions) could benefit from more human‑relevant research models, improving drug safety and efficacy and potentially reducing clinical‑trial failure rates.
Taxpayers, researchers, and the public will gain greater transparency through standardized animal‑use reporting, grant documentation of alternatives, and biennial reduction plans, enabling better oversight and targeted funding for alternatives.
Taxpayers will incur new federal costs to create and operate a new NIH center and related programs, which could increase spending or require trade‑offs with other research priorities.
Researchers, universities, and hospitals will face added administrative and compliance burdens (exhaustive alternative searches, documentation in proposals, and biennial reporting), raising time and costs for grant preparation and program administration.
Patients and research programs could see delays if mandated evaluation of all satisfactory nonanimal methods or slow validation of new alternatives blocks or postpones some animal studies and regulatory decisions.
Based on analysis of 5 sections of legislative text.
Creates an NIH center to promote nonanimal research methods, strengthens NIH rules to prioritize alternatives, and mandates public biennial reporting of animals used in federally funded research.
Introduced February 13, 2025 by Ken Calvert · Last progress February 13, 2025
Creates a new NIH center to promote and coordinate nonanimal, human-relevant research methods and changes NIH policies to prioritize and document alternatives to animal testing. Requires entities that receive federal research funds (and federal agencies that use animals) to publicly report animal use totals by species every two years, submit reduction plans, and follow strengthened procedures to search for and justify the use of animals in NIH-conducted or -supported research.