Reorganizes and renumbers subsection (a) text into subparagraphs/clauses; limits the scope language to research conducted or supported by the National Institutes of Health; adds requirements to establish/maintain animal care guidelines and to create incentives and procedures promoting the use and evaluation of scientifically satisfactory nonanimal methods (including reviewer expertise and access to a reference librarian and guidelines for search procedures); adds an assurance requirement to subsection (c)(1) that a scientifically satisfactory nonanimal method is not available; and updates a cross-reference in subsection (b)(1) from subsection (a)(3) to subsection (a)(1)(C).

Redesignates the existing paragraph (25) as paragraph (26) and inserts a new paragraph (25) into subsection (b) naming the National Center for Alternatives to Animals in Research and Testing as a national center.

Makes a conforming amendment to subsection (d)(1) by striking and inserting text (specific replacement text not provided) to reflect the change in the number/listing of institutes and centers.

Adds a new subpart to Part E of title IV by inserting a new subpart after subpart 5 to establish and set out duties for the National Center for Alternatives to Animals in Research and Testing (specific subpart text not provided).