Innovate to Save Lives Act · Introduced in House (2025-07-21)

SEC. 2. Credit for research activities of small businesses related to the mitigation of certain drug threats

(a) In general

of the Internal Revenue Code of 1986 is amended by striking at the end of paragraph (2), by striking the period at the end of paragraph (3) and inserting , and, and by adding at the end the following new paragraph: Section 41(a)
- in the case of a small business (as defined in subsection (b)(3)(D)(iii)), 10 percent of the qualified drug threat mitigation research expenses (as defined in subsection (i)) for the taxable year.

(b) Definitions

(i) Qualified drug threat mitigation research expenses
- For purposes of this section—
- (1) Qualified drug threat mitigation research expenses
  - The term means the qualified research expenses which would be determined under subsection (b) if were substituted for each place it appears therein. ``qualified drug threat mitigation research expenses
- (2) Qualified drug threat mitigation research
  - The term means qualified research which is undertaken for the purpose of discovering information related to mitigating or treating the effects of the use of a specified drug or to preventing, diverting, or intervening in such use. Such term shall not include any clinical research unless such research complies with the policies and guidelines of the National Institutes of Health for clinical research. qualified drug threat mitigation research
- (3) Specified drug
  - (A) In general
    - The term means any emerging drug, fentanyl, fentanyl-related substance, or methamphetamine. specified drug
  - (B) Emerging drug
    - The term means a drug designated as an emerging drug threat under section 709(c) of the Office of National Drug Control Policy Reauthorization Act of 1998 (). Such term shall include any such drug for any taxable year if such designation is in effect under such section at any time during such taxable year. 21 U.S.C. 1708(c)
  - (C) Fentanyl-related substance
    - The term means any substance that is structurally related to fentanyl by 1 or more of the following modifications: fentanyl-related substance
      - (i) By replacement of the phenyl portion of the phenethyl group by any monocycle, whether or not further substituted in or on the monocycle.
      - (ii) By substitution in or on the phenethyl group with alkyl, alkenyl, alkoxyl, hydroxyl, halo, haloalkyl, amino, or nitro groups.
      - (iii) By substitution in or on the piperidine ring with alkyl, alkenyl, alkoxyl, ester, ether, hydroxyl, halo, haloalkyl, amino, or nitro groups.
      - (iv) By replacement of the aniline ring with any aromatic monocycle whether or not further substituted in or on the aromatic monocycle.
      - (v) By replacement of the N–propionyl group with another acyl group.
Section 41 of such Code is amended by adding at the end the following new subsection:

The amendments made by this section shall apply to taxable years beginning after the date of the enactment of this Act.

(d) GAO report

5 years after the date of the enactment of this Act, the Comptroller General shall submit a written report to Congress regarding the amount of tax credits allowed under of the Internal Revenue Code of 1986 for qualified drug threat mitigation expenses and the types of qualified drug threat mitigation research with respect to which such credits were allowed. The Comptroller General shall ensure that the data in such report is anonymous and that any studies undertaken to prepare such report do not impede qualified drug threat mitigation research. section 41(a)(4)

H.R. 4573

Table of contents

SEC. 1. Short title