Creates a nonregulatory Mississippi River Restoration and Resilience Initiative (MRRRI) housed at EPA to coordinate and fund projects that improve water quality, restore habitat, reduce flood and storm risk, address invasive species, strengthen partnerships, and expand monitoring and science across the Mississippi River Corridor. It also establishes a national program office and a network of three research centers run by DOI/USGS, requires near-term measurable goals and an action plan, and mandates periodic updates and annual public reporting to Congress.

The measure directs EPA, Interior, and USGS to set timelines and performance metrics (goals within 1 year, an action plan within 2 years, updates at least every 5 years), create public science plans and forums, and use the newly defined statutory terms for program administration. It focuses on coordination, planning, research, and grantable project support rather than new regulatory controls.