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Congressional Daily Record
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April 27, 2026
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Download official Extensions PDFReturn to issue contextCONGRATULATING DR. MARY E. BRUNKOW AND THE INSTITUTE FOR SYSTEMS
BIOLOGY ON WINNING THE 2025 NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE
HON. PRAMILA JAYAPAL
of washington
in the house of representatives
Monday, April 27, 2026
Ms. JAYAPAL. Mr. Speaker, I rise today to extend my heartfelt congratulations to Dr. Mary E. Brunkow and the Institute for Systems Biology (ISB) in Seattle on the award of the 2025 Nobel Prize in Physiology or Medicine, one of the most prestigious honors in science.
A resident of Seattle and a Distinguished Investigator at ISB, Dr. Brunkow has made transformative contributions to immunology through her groundbreaking research on regulatory T cells and the FOXP3 gene, a key regulator of peripheral immune tolerance—the process by which the immune system avoids attacking the body's own tissues. In collaboration with Dr. Fred Ramsdell and building on foundational work by Dr. Shimon Sakaguchi, she helped uncover the genetic and cellular mechanisms that safeguard immune balance, reshaping the field and laying the foundation for new treatments for autoimmune diseases, improved organ transplantation, and cancer immunotherapy.
Dr. Brunkow's pioneering work has fundamentally advanced our understanding of how the immune system functions and stands as a powerful example of the kind of federally supported biomedical research that improves lives, fuels innovation, and keeps the United States at the forefront of global scientific leadership.
investment in science. Dr. Brunkw's work is a reminder of why we must continue to support institutions like ISB and ensure that scientists have the resources they need to make the next breakthrough.
scientific community, I extend my deepest congratulations to Dr. Mary E. Brunkow. Her discoveries have reshaped medicine and immunology, and her legacy will continue to inspire future generations of scientists, clinicians, and innovators. I urge my colleagues to join me in celebrating her extraordinary contributions to science, health, and humanity, and to recommit to strong, sustained federal investment in biomedical research.