Adds a new section (Section 553) to Part D of title V of the Public Health Service Act establishing a grants/contracts/cooperative agreements program to prevent and reduce underage cannabis use, defining eligible entities, permitted uses, priority considerations, supplement-not-supplant requirement, funding, and definitions.

Adds multiple new definitions related to cannabis and cannabinoid products (including definitions for 'cannabis', 'cannabinoid', 'cannabinoid product', 'semi-synthetic cannabinoid', 'tetrahydrocannabinol', 'artificially or synthetically derived cannabinoid', 'intended for human consumption', and 'serious adverse effect').

Inserts references to a new section (1103) in various paragraphs and adds new prohibited-act subsections specific to cannabinoid products (including sale/distribution to persons under 21; sale/distribution of cannabinoid products containing alcohol, tobacco, nicotine, or other interacting substances as determined by the Secretary; failure of manufacturers/distributors to notify the Attorney General of cannabinoid products used in illicit trade; introduction/delivery of adulterated or misbranded cannabinoid products; and other cannabinoid-product-specific prohibitions).

Adds new civil monetary penalty provisions specific to violations involving cannabinoid products, including (A) a general civil penalty not to exceed $15,000 per violation and $15,000,000 total per proceeding; (B) enhanced civil penalties for knowing violations (up to $250,000 per violation and up to $10,000,000 total), and escalating continuing-violation penalties tied to 30‑day periods (initial $250,000 for first 30‑day period, doubling each 30 days, with caps described); and (C) authority to impose no-cannabinoid-product-sale orders for repeated violations at retail or online outlets, with hearing rights.

Amends seizure provisions to include 'cannabinoid product' alongside existing categories (e.g., food, drug, device, tobacco product) in the grounds and jurisdiction provisions and related paragraphs, thereby extending seizure authority to cannabinoid products.

Extends factory and facility inspection provisions to cover cannabinoid products by inserting references to 'cannabinoid products' into subsection (a) and related inspection text and into subsection (b)(1).

Amends the publicity provisions (section 705(b)) by inserting references to cannabinoid products so that dissemination/publication authorities applying to information about goods may explicitly include cannabinoid products.

Modifies the presumption-of-jurisdiction provision by inserting references to cannabinoid products (adding cannabinoid products into the list of articles for which the connection with interstate commerce is presumed).