Amends section 241(1)(A) of the Higher Education Act (20 U.S.C. 1033(1)(A)) by striking specified clauses and redesignating others.

Repeals section 317 (20 U.S.C. 1059d) (one of the part A Minority-Serving institutions provisions).

Repeals section 318 (20 U.S.C. 1059e).

Repeals section 319 (20 U.S.C. 1059f).

Repeals section 320 (20 U.S.C. 1059g).

Amends the part heading and section 350 (20 U.S.C. 1067) to change descriptive language, strike paragraph (3), redesignate paragraphs, and replace references to minority underrepresentation with language focused on students who receive a Federal Pell Grant.

Renames the 'Minority Institutions Science Improvement Program' to the 'Science Opportunity Improvement Program' and revises the program's stated focus to individuals who receive a Federal Pell Grant.

Modifies Applicant priority and selection language to shift emphasis toward supporting engagement of Federal Pell Grant recipients in STEM fields.

Revises examples of authorized activities to replace references to 'minority undergraduate students' and 'minorities' with references to students or individuals who receive a Federal Pell Grant.

Amends section 356 (20 U.S.C. 1067e–1) by striking specified paragraphs, redesignating others, revising priority language to emphasize appeals to Pell Grant recipients, and adding a prohibition that the campaign shall not provide special treatment or consider race or ethnicity.