Designates October 2025 as "Substance Use & Misuse Prevention Month" and expresses the Senate’s support for effective prevention programs, efforts to reduce addiction and overdoses, and activities that promote treatment and recovery. It also lists findings about the scale of substance use, misuse, and related treatment needs in the United States using 2024 estimates.

The resolution is nonbinding and symbolic: it encourages prevention and response activities and raises awareness but does not authorize spending, create new programs, or impose legal requirements.