Makes targeted changes to Medicare payment and coverage rules to preserve and clarify payment for home infusion therapy starting January 1, 2026. The bill updates the definition of home infusion drugs to add a category for certain IV antibacterials/antifungals/antivirals given without a pump, creates transitional and reduced-payment rules for home infusion services (including basing transitional payment on 5 hours of infusion for specified years and reduced payment when a supplier is not physically present), allows nurse practitioners and physician assistants to establish and review home infusion plans of care, and prevents duplicate Medicare payments for listed infusion supplies when the same therapy and drug were already paid under the home infusion benefit.