Creates a Presidentially directed Joint Task Force to Counter Illicit Synthetic Narcotics (JTF–ISN) that centralizes and coordinates federal efforts to identify, investigate, disrupt, and prosecute networks supplying illicit synthetic narcotics (especially fentanyl and related opioids). The Director, appointed by the President with Senate confirmation, will lead multi-agency operations, produce regular strategy reports and briefings (including a required 2‑year plan), coordinate sanctions and joint law enforcement actions, and focus on transnational suppliers and networks while explicitly prohibiting targeting for personal drug use or isolated low‑level dealing.