Requires the Secretary of Health and Human Services to issue best-practice guidance within 12 months to State Medicaid and CHIP agencies, the Indian Health Service, Indian Tribes and tribal organizations, and Urban Indian organizations on preventing, screening, testing, treating, and educating about syphilis and congenital syphilis. The guidance must address third‑trimester and delivery screening, telehealth, patient education, and timely treatment.

Also requires the Secretary to report to Congress within two years on how those best practices were implemented. The law is focused on reducing rising syphilis rates and preventing congenital syphilis by improving screening and care during pregnancy.