Requires U.S. agencies to promote and protect the rights of LGBTQI people domestically and abroad by allowing self-selected sex markers on certain identity documents, changing how U.S. citizenship is transmitted for some children born abroad via assisted reproduction, expanding diplomatic support and protections for LGBTQI U.S. employees and their families, documenting and responding to criminalization and violence against LGBTQI people worldwide, and creating sanctions, reporting, assistance funds, and program requirements to advance equality. It also strengthens refugee, asylum, and immigration protections for people targeted for persecution based on sexual orientation, gender identity, or sex characteristics, and directs changes to foreign assistance, PEPFAR implementation, and diplomatic reporting and training with specific deadlines for regulations and reports.