Adds a new subsection (p) to 42 U.S.C. 282 prohibiting the Secretary, acting through the Director of NIH, from cancelling, delaying, or suspending covered agreements except under specified written findings, requires notification to specified congressional committees within 30 days, and mandates implementation in accordance with agreement terms for the full period specified.

Amends 42 U.S.C. 281 (Section 401 of the Public Health Service Act) by redesignating existing subsections (g) and (h) as (h) and (i), respectively, and inserting a new subsection (g) that prohibits most political employees from being employed by the NIH or participating in implementation of general policies for management and operation of NIH programs and activities, with specified exceptions.

Adds a new subsection (r) to Section 2 of the Public Health Service Act that defines the term "political employee" and enumerates categories of positions covered (positions under 5 U.S.C. 5312–5316; noncareer SES appointments per 5 U.S.C. 3132(a); Schedule C positions under 5 CFR part 213 subpart C; Schedule G of the excepted service established by Executive Order 14317; other positions excepted from the competitive service for confidential or policy roles; and individuals acting on behalf of such positions).